Pitted keratolysis is a bacterial infection of the skin that affects the soles of the feet or the palms of the hands. People with physical jobs that require them to wear enclosed footwear for extended periods, such as those working as farmers or soldiers, may be more likely to develop the infection because bacteria thrive in dark, moist conditions. In this article, learn more about pitted keratolysis, including its causes, symptoms, and treatment. Share on Pinterest Pitted keratolysis can affect both the feet and hands. Image credit: Evan Saap, 2016 Pitted keratolysis is a bacterial infection of the skin. It can affect the palms of the hands and, more commonly, the soles of the feet, particularly the weight-bearing areas. This infection causes small depressions, or pits, in the top layer of the skin. It can also lead to a bad smell. Pitted keratolysis usually affects people who wear enclosed warm footwear for long periods, including soldiers, sailors, and athletes. It also tends to be ...